Officials told Reuters that 15 people were killed.
"An air strike missed its target and hit a wedding car convoy, ten people were killed immediately and another five who were injured died after being admitted to the hospital," a security official told Reuters.
According to the report, five more people were injured.
The officials say Thursday's attack took place in the Yemeni city of Radda, the capital of Bayda province. The city is known as a stronghold of Al Qaeda militants.
They said the convoy was heading to a wedding in the village of Qaifa when it was hit by the drone, and that the strike left charred bodies in the road and vehicles on fire.
One official said that Al Qaeda militants are suspected to have been traveling with the wedding convoy.
The officials spoke on condition of anonymity because they were not authorized to brief the media.
The U.S. considers Yemen's Al Qaeda branch to be among the most active in the world. Yemen is among a handful of countries where the U.S. acknowledges using drones, although it does not comment on the practice, Reuters reported.
The Associated Press contributed to this report.